| Active Ingredient | Pyrimethamine And Sulphamethoxazole |
| Brand | Pyrethon S |
| Country of origin | India |
| Form | Oral Tablet |
Pyrethon S 500 Tablet is an oral tablet used for managing malaria and certain parasite infections. This medicine has two active compounds Pyrimethamine and Sulphamethoxazole.
Clinical Uses
Pyrethon S 500mg is used for managing and preventing malaria, especially in cases where the malaria parasite has developed resistance to other malaria medicines. This medicine is also used as a presumptive treatment for malaria in travelers in regions with high malaria outbreaks.
How It Works
Pyrethon S 500mg contains two active ingridient and each of them have a different mechanism of action.
- Pyrimethamine works by inhibiting the enzyme dihydrofolate reductase (DHFR) which is responsible for converting one form of folate into another active form which is important for the malaria parasite for DNA synthesis and cell growth.
- Sulfadoxine inhibits another enzyme dihydropteroate synthase (DHPS) that prevents the conversion of a compound into a precursor of folate. This precursor is important for the parasite to produce folate.
Side Effects
A few side effects associated with Pyrethon S 500mg include-
- Diarrhoea
- Nausea
- Skin rash
- Anemia
- Vomiting
It is important to consult a doctor if you experience any of these side effects-
- convulsion
- leukopenia
- glossitis
- megaloblastic anemia
- crystalluria
- central nervous system stimulation
Precautions & Warnings
- Patients with megaloblastic anemia caused due to deficiency of folate should not take this medicine unless prescribed by a doctor.
- People with liver and kidney issues should use this medicine with caution.
- Pyrethon S 500mg may cause dizziness and fatigue making it unsafe to drive or operate heavy machines.
- It is advised to avoid using this medicine during breastfeeding and pregnancy.
- Drink enough water while taking this medicine to prevent crystallisation in urine.
- Avoid consuming alcohol while taking this medicine as it may increase the risk of side effects.
- Even if you feel better it is important to finish the course of this medicine.
Drug Interactions
Some of the medicine that should not be taken with Pyrethon S 500mg include-
- auranofin
- cyclosporine
- deferiprone
- ketoconazole
- levoketoconazole
- methenamine
- pexidartinib
- warfarin
This is not a complete list of all possible drug interactions Pyrethon S 500mg. It is important to consult a doctor before taking any medicine or supplement with Pyrethon S tablets.
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